Pathol Res Pract. Epub 2002 Jan 4. Malignant Dedifferentiated liposarcoma Myxoid liposarcoma Pleomorphic liposarcoma Liposarcoma, not otherwise specified. Stata 12.1 software was used to produce descriptive statistics regarding age, sex, race, disease grade, disease stage, and tumor, node, metastasis classification …  |  • Benign spindle cell tumor with adipocytic component (spin- dle cell lipoma-like tumor) • Solitary fibrous tumor Myofibroblastic tumors • Myofibroblastoma • Leiomyoma? Cases << Back to overview Case ID: 171. This site needs JavaScript to work properly. Although such neoplasms exhibit morphological and immunophenotypical heterogeneity, they actually represent variations of the same tumor entity, likely arising from the uncommitted vimentin+/CD34+ fibroblasts of the mammary stroma, capable of multidirectional mesenchymal differentiation. Yoshimoto T, Takahashi-Fujigasaki J, Inoshita N, Fukuhara N, Nishioka H, Yamada S. Brain Tumor Pathol. GFAP, vimentin, S100, galectin-3, EMA, and CD68 were variably positive in the majority of the 3 tumor groups. There is no definite known cause for this type of tumour, but it can sometimes occur as a result of previous radiotherapy treatment. Spindle cell / pleomorphic lipoma Hibernoma. Spindle cell proliferations of diverse types which vary greatly in their behavior may occur in the urinary bladder. [5] Retiform hemangioendothelioma (also known as a "Hobnail hemangioendothelioma" [3] ) is a low-grade angiosarcoma , first described in 1994, presenting as a slow-growing exophytic mass, dermal plaque, … This classification includes neural, myofibroblastic, muscle, fibroblastic, vascular, epithelial, odontogenic and miscellaneous tumors. Spindle cell sarcoma stage 4 – This is a severe stage wherein the tumor has spread to other parts of the body including the lymph nodes. (1, 2, 3, 4, 5) Image 1: A primary tumor categorized as intermediate grade spindle cell sarcoma. Figure B showing the MRI scan of the affected part of the body Purely benign mesenchymal spindle cell neoplasms of the breast are currently labeled under various terms in the literature (benign spindle cell tumor, fibroma, spindle cell lipoma, myofibroblastoma, solitary fibrous tumor, myogenic stromal tumor). Medicine (Baltimore). SMA+, ALK+ (about 55%, especially childhood visceral tumors) ALK gene rearrangements. Spindle cells are of mesenchymal origin, and form the body's connective tissue, fat, muscle, bone, cartilage and blood vessels. cell or spindle cell tumor cell morphology, high-grade myxoid liposarcoma carries the same prognostic information, with a greaterfrequencyofmetastasisandworsesurvivalcomparedwithlow-gradetumors. Practical approach to diagnosis of bland-looking spindle cell lesions of the breast.  |  Cytogenetic studies of spindle cell tumour show two cell lines containing balanced translocation between chromosomes 7 and 16. Classification of BSCT of the mammary stroma Fibroblastic tumors • Benign spindle cell tumor N.O.S. 17 These are bulky intraluminal masses that most often develop in the mid esophagus of middle-aged to elderly men (80%). Pituicytomas, a mis-diagnosed benign tumor of the neurohypophysis: report of three cases. We investigated 7 spindle cell oncocytomas, 4 pituicytomas, and 3 granular cell tumors for their genetic (BRAF(V600E) mutation and BRAF-KIAA fusion), immunohistochemical (GFAP, vimentin, S100 protein, olig2, IDH1-R132H, NF, galectin-3, chromogranin-A, CD56, EMA, CAM5.2, CD68, TTF-1, and bcl-2), and ultrastructural features to refine their classification. USA.gov. Pathologica. Clipboard, Search History, and several other advanced features are temporarily unavailable. We investigated 7 spindle cell oncocytomas, 4 pituicytomas, and 3 granular cell tumors for their genetic (BRAF(V600E) mutation and BRAF-KIAA fusion), immunohistochemical … 2020 Feb 22;12(2):514. doi: 10.3390/cancers12020514. Hypothalamic Endocrine Tumors: An Update. Diagn Pathol. According to the most recent 2015 World Health Organization (WHO) classification, PSC includes several different variants of malignant epithelial tumors (carcinomas) histologically mimicking sarcomas showing or entirely lacking a conventional component of non-small cell lung cancer (NSCLC). Juxtaglomerular cell tumor Renomedullary interstitial cell tumor Schwannoma Solitary fibrous tumor Mixed epithelial and stromal tumor family. Please enable it to take advantage of the complete set of features! 2018;69(2):189-194. doi: 10.5114/pjp.2018.76703. Stromal tumors of the lower female genital tract: histogenetic, morphological and immunohistochemical similarities with the "benign spindle cell tumors of the mammary stroma". Myofibroblastoma of the Breast: Literature Review and Case Report. Chondrolipoma of the breast as a rare variant of myofibroblastoma: an immunohistochemical study of two cases. Benign intrascrotal spindle cell tumors are rare lesions and most of them are located in paratesticular region. Well differentiated neuroendocrine tumor Large cell neuroendocrine carcinoma Small cell neuroendocrine carcinoma Paraganglioma 3 and 4) the tumor was found to be of loose texture with many hemorrhagic areas and rich in new blood-vessels. To cover the entire spectrum of such lesions, the term "benign spindle cell tumors (BSCTs) of the mammary stroma" is advocated. Tumor Classification. Is spindle cell oncocytoma a true entity or a variant of pituicytoma? Focal sclerosis without spindle cells. 2016 Mar 25;11:33. doi: 10.1186/s13000-016-0480-8. 2002 Mar;440(3):249-60. doi: 10.1007/s00428-001-0572-y. All tumors were negative with the IDH1-R132H mutation-specific antibody, and none had evidence of BRAF alterations (BRAF(V600E) mutation and BRAF-KIAA fusion). Monophasic spindle cell lesions of the breast can be divided morphologically into inflammatory/reactive (fibrous scar, desmoid fibromatosis and nodular fasciitis), low-grade (myofibroblastoma, fibromatosis-like metaplastic carcinoma, neural and lipomatous tumors), and high-grade (monophasic spindle cell metaplastic carcinoma, metaplastic carcinoma with heterologous components, sarcomas and … 2018 Sep-Oct;66(5):1413-1418. doi: 10.4103/0028-3886.241353. ISUP Home Pathology Imagebase Classification of renal tumors. Trouillas J, Jaffrain-Rea ML, Vasiljevic A, Raverot G, Roncaroli F, Villa C. Cancers (Basel). Occasional larger polygonal cells. NIH Fibroma of the breast: a rare tumour in the spectrum of the benign spindle cell tumours of the mammary stroma. Necrosis was absent in 17 tumors and ≤50% in 20 tumors. USA.gov. Pituitary spindle cell oncocytoma presented as pituitary apoplexy. Pituicytes have 5 ultrastructural variants: light, dark, granular, ependymal, and oncocytic. Clipboard, Search History, and several other advanced features are temporarily unavailable. NLM 2007;203(11):827-9. doi: 10.1016/j.prp.2007.08.005. CLASSIFICATION OF LUNG TUMOURS  Primary  Epithelial –Adeno carcinoma -Squamous cell carcinoma -Adenosquamous carcinoma -Neuro endocrine tumors -Large cell carcinoma -Salivary gland tumours -Sarcomatoid carcinomas  Mesenchymal • Pulmonary hamartoma • Chondroma • PEComatous tumors  Lymphohistiocytic tumors  Ectopic origin  Metastatic Spindle cell malignancies of the breast were identified as International Classification of Diseases for Oncology, Third Edition, code 8004/3 for malignant tumor, spindle cell type, 8032/3 for SpCC, and 8801/3 for spindle cell sarcoma. Based on the morphologic and immunohistochemical findings, the following histotypes were identified: (i) tumors (10/19 cases) with the characteristic morphology of myofibroblastoma and stained with vimentin, CD34, desmin, and α-smooth muscle actin; (ii) fibroblastic benign spindle cell tumors (5/19 cases) composed of fibroblast-like cells stained only with vimentin and CD34; (iii) tumors (2/19 cases) … A case report of a mammary myofibroblastoma in a male and literature review of radiologic and pathologic features of breast myofibroblastoma. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Epub 2002 Jun 19. Thus, this rare subheading of lung neoplasms includes pleomorphic carcinoma, spindle cell carcinoma, giant cell … Spindle cell sarcoma is a rare malignant (cancerous) tumour which can develop in the bone or soft tissue. Some of them such as the inflammatory pseudotumor and the postoperative spindle cell nodule are reactive and clinically benign although they may be responsible for significant symptoms. Leiomyosarcoma. Surg Pathol Clin. On histologic examination (Figs.  |  2019 Dec;111(4):344-360. doi: 10.32074/1591-951X-31-19. 2017 Apr;20(2):211-217. doi: 10.1007/s11102-016-0762-x. J Surg Case Rep. 2019 Jun 14;2019(6):rjz179. Awareness of this entity including its unique morphologic and immunophenotypic features as well as its interchangeable kinase gene fusions is crucial for correct classification and … F > M Bland-looking spindle cell lesions of the breast comprise a heterogeneous group of tumor-like and tumor entities, ranging from reactive to low-grade malignant neoplasms with metastatic potential 1.(. Spindle cell carcinoma, also termed carcinosarcoma, pseudosarcoma, polypoid carcinoma, sarcomatoid carcinoma, and spindle cell variant of squamous cell carcinoma, is a rare type of malignant tumor that often grows as an exophytic polypoid lesion (see also Chapter 20). Spindle cell neoplasms can affect the oral cavity. Kidney Int Rep. 2019 Nov 6;5(2):231-234. doi: 10.1016/j.ekir.2019.10.010. This classification is based on the predominance of spindle cells in the histopathology of the lesions of the oral cavity. NCI CPTC Antibody Characterization Program. Hagel C, Buslei R, Buchfelder M, Fahlbusch R, Bergmann M, Giese A, Flitsch J, Lüdecke DK, Glatzel M, Saeger W. Pituitary.  |  Toggle navigation. BSCTs can be subtyped into four main groups by light microscopy (LM) and immunocytochemistry (ICC): fibroblastic, myofibroblastic, fibrohistiocytic, and mixed forms. Epub 2017 Dec 9. Spindle cell tumors are a heterogeneous group of skin neoplasms. : 599 These tumors were reclassified by Dr. Weiss in 1996 as "spindle cell hemangioma", rather than hemangioendothelioma, due to the excellent prognosis observed in a group of 78 patients. Spindle cell neoplasms are dened as neoplasms that consist of spindle-shaped cells in the histopathology. Epithelial tumors include tumors of epithelial tissue origin. Recent data suggest that, whereas pituicytes and all 3 tumor types are positive for TTF-1, folliculostellate cells are negative for TTF-1. 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